What are the Most Dangerous Drugs to Mix?


Oftentimes, people will mix drugs to achieve a more desired “high”. Despite warning labels, millions of people have combined several different drugs with the belief that nothing can harm them. Mixing two or more drugs may not only intensify the effects of each drug, but may also cause serious complications. Combining drugs is a dangerous act and could result in lethal consequences, that’s why it’s always important to speak with a doctor immediately if you are experiencing any adverse reactions from combining drugs. According to Medical Daily, some of the most dangerous drug and alcohol combinations include:

  • Benzodiazepines and alcohol. Both substances are depressants, and can reduce the heart rate and slow the central nervous system so much that it could lead to a coma or even death.
  • Opiates and alcohol. Again – both are depressants, and the effects could include depressed breathing rate, severely compromised motor coordination, loss of consciousness, a coma, or death.
  • Antidepressants and alcohol. Antidepressants can increase the intensity of alcohol. When combined, there are increased risks of dizziness, seizures, confusion, and coma.
  • Stimulants and alcohol. Stimulants speed up the body, increasing blood pressure which can mask the effects of alcohol. Combining drugs such as cocaine and alcohol produces a large amount of coca ethylene, a chemical that forms in the liver. This chemical places significant stress on the cardiovascular system, including the heart and lungs.
  • Birth control and alcohol. After taking birth control, a woman’s body takes about 3 hours to reach the bloodstream and drinking alcohol makes it more difficult for the body to metabolize the main ingredient in alcohol. This means that it takes longer for the alcohol to leave the body, inhibiting a woman’s decision-making skills and causing her to potentially drink past intoxication.
  • Over-the-counter drugs and alcohol. Previous studies have shown that acute liver failure has been linked with consuming too many Tylenols along with alcohol. Harvard Medical School states that while 32 million Americans take cholesterol-lowering medications each year, combining them with alcohol could place the body at risk for failure over time.


Extreme caution is to be taken when combining drugs and prescription medications with alcohol or with each other. Always read the warning labels, and always consult a physician prior to combining anything – it could save your life.

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